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- Title
Angiogenesis: Tumorigenesis and the angiogenic switch.
- Authors
Bergers, Gabriele; Benjamin, Laura E.
- Abstract
It has become evident that we cannot understand tumour growth without considering components of the stromal microenvironment, such as the vasculature. At the same time, the tumour phenotype determines the nature of the tumour vasculature. Much research is now devoted to determining the impact of angiogenesis on tumour development and progression, and the reciprocal influences of tumour products on the microvasculature. A more detailed understanding of the complex parameters that govern the interactions between the tumour and vascular compartments will help to improve anti-angiogenic strategies -- not only for cancer treatment, but also for preventing recurrence.
- Publication
Nature Reviews Cancer, 2003, Vol 3, Issue 6, p401
- ISSN
1474-175X
- Publication type
Academic Journal
- DOI
10.1038/nrc1093