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- Title
Melanopsin in cells of origin of the retinohypothalamic tract.
- Authors
Gooley, J J; Lu, J; Chou, T C; Scammell, T E; Saper, C B
- Abstract
All known eukaryotic organisms exhibit physiological and behavioral rhythms termed circadian rhythms that cycle with a near-24-hour period; in mammals, light is the most potent stimulus for entraining endogenous rhythms to the daily light cycle. Photic information is transmitted via the retinohypothalamic tract (RHT) to the suprachiasmatic nucleus (SCN) in the hypothalamus, where circadian rhythms are generated, but the retinal photopigment that mediates circadian entrainment has remained elusive. Here we show that most retinal ganglion cells (RGCs) that project to the SCN express the photopigment melanopsin.
- Publication
Nature neuroscience, 2001, Vol 4, Issue 12, p1165
- ISSN
1097-6256
- Publication type
Journal Article
- DOI
10.1038/nn768