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- Title
Homeostatic regulation of MeCP2 expression by a CREB-induced microRNA.
- Authors
Klein, Matthew E; Lioy, Daniel T; Ma, Lin; Impey, Soren; Mandel, Gail; Goodman, Richard H
- Abstract
Both increases and decreases in methyl CpG-binding protein 2 (MeCP2) levels cause neurodevelopmental defects. We found that MeCP2 translation is regulated by microRNA 132 (miR132). Block of miR132-mediated repression increased MeCP2 and brain-derived neurotrophic factor (BDNF) levels in cultured rat neurons and the loss of MeCP2 reduced BDNF and miR132 levels in vivo. This feedback loop may provide a mechanism for homeostatic control of MeCP2 expression.
- Publication
Nature neuroscience, 2007, Vol 10, Issue 12, p1513
- ISSN
1097-6256
- Publication type
Journal Article
- DOI
10.1038/nn2010