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- Title
Pharmacotherapy for cognitive impairment in a mouse model of Down syndrome.
- Authors
Fernandez, Fabian; Morishita, Wade; Zuniga, Elizabeth; Nguyen, James; Blank, Martina; Malenka, Robert C; Garner, Craig C
- Abstract
Ts65Dn mice, a model for Down syndrome, have excessive inhibition in the dentate gyrus, a condition that could compromise synaptic plasticity and mnemonic processing. We show that chronic systemic treatment of these mice with GABAA antagonists at non-epileptic doses causes a persistent post-drug recovery of cognition and long-term potentiation. These results suggest that over-inhibition contributes to intellectual disabilities associated with Down syndrome and that GABAA antagonists may be useful therapeutic agents for this disorder.
- Publication
Nature neuroscience, 2007, Vol 10, Issue 4, p411
- ISSN
1097-6256
- Publication type
Journal Article
- DOI
10.1038/nn1860