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- Title
Preferential incorporation of adult-generated granule cells into spatial memory networks in the dentate gyrus.
- Authors
Kee, Nohjin; Teixeira, Cátia M; Wang, Afra H; Frankland, Paul W
- Abstract
Throughout adulthood, new neurons are continuously added to the dentate gyrus, a hippocampal subregion that is important in spatial learning. Whether these adult-generated granule cells become functionally integrated into memory networks is not known. We used immunohistochemical approaches to visualize the recruitment of new neurons into circuits supporting water maze memory in intact mice. We show that as new granule cells mature, they are increasingly likely to be incorporated into circuits supporting spatial memory. By the time the cells are 4 or more weeks of age, they are more likely than existing granule cells to be recruited into circuits supporting spatial memory. This preferential recruitment supports the idea that new neurons make a unique contribution to memory processing in the dentate gyrus.
- Publication
Nature neuroscience, 2007, Vol 10, Issue 3, p355
- ISSN
1097-6256
- Publication type
Journal Article
- DOI
10.1038/nn1847