We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
A neuregulin 1 variant associated with abnormal cortical function and psychotic symptoms.
- Authors
Hall, Jeremy; Whalley, Heather C; Job, Dominic E; Baig, Ben J; McIntosh, Andrew M; Evans, Kathryn L; Thomson, Pippa A; Porteous, David J; Cunningham-Owens, David G; Johnstone, Eve C; Lawrie, Stephen M
- Abstract
NRG1, encoding neuregulin 1, is a susceptibility gene for schizophrenia, but no functional mutation causally related to the disorder has yet been identified. Here we investigate the effects of a variant in the human NRG1 promoter region in subjects at high risk of schizophrenia. We show that this variant is associated with (i) decreased activation of frontal and temporal lobe regions, (ii) increased development of psychotic symptoms and (iii) decreased premorbid IQ.
- Publication
Nature neuroscience, 2006, Vol 9, Issue 12, p1477
- ISSN
1097-6256
- Publication type
Journal Article
- DOI
10.1038/nn1795