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- Title
Capacity for 5-HT<sub>1A</sub>–mediated autoregulation predicts amygdala reactivity.
- Authors
Fisher, P. M.; Meltzer, C. C.; Ziolko, S. K.; Price, J. C.; Hariri, A. R.
- Abstract
We examined the contribution of 5-HT1A autoreceptors (with [11C]WAY100635 positron emission tomography) to amygdala reactivity (with blood oxygenation level–dependent functional magnetic resonance imaging) in 20 healthy adult volunteers. We found a significant inverse relationship wherein 5-HT1A autoreceptor density predicted a notable 30–44% of the variability in amygdala reactivity. Our data suggest a potential molecular mechanism by which a reduced capacity for negative feedback regulation of 5-HT release is associated with increased amygdala reactivity.
- Publication
Nature Neuroscience, 2006, Vol 9, Issue 11, p1362
- ISSN
1097-6256
- Publication type
Academic Journal
- DOI
10.1038/nn1780