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- Title
A genetic interaction between the vesicular acetylcholine transporter VAChT/UNC-17 and synaptobrevin/SNB-1 in C. elegans.
- Authors
Sandoval, Gisela M; Duerr, Janet S; Hodgkin, Jonathan; Rand, James B; Ruvkun, Gary
- Abstract
Acetylcholine, a major excitatory neurotransmitter in Caenorhabditis elegans, is transported into synaptic vesicles by the vesicular acetylcholine transporter encoded by unc-17. The abnormal behavior of unc-17(e245) mutants, which have a glycine-to-arginine substitution in a transmembrane domain, is markedly improved by a mutant synaptobrevin with an isoleucine-to-aspartate substitution in its transmembrane domain. These results suggest an association of vesicular soluble N-ethylmaleimide-sensitive-factor attachment protein receptor (SNARE) components with vesicular neurotransmitter transporters.
- Publication
Nature neuroscience, 2006, Vol 9, Issue 5, p599
- ISSN
1097-6256
- Publication type
Journal Article
- DOI
10.1038/nn1685