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- Title
Adenosine A<sub>2A</sub>, but not A<sub>1</sub>, receptors mediate the arousal effect of caffeine.
- Authors
Zhi-Li Huang; Wei-Min Qu; Naomi Eguchi; Jiang-Fan Chen; Schwarzschild, Michael A.; Fredholm, Bertil B.; Urade, Yoshihiro; Hayaishi, Osamu
- Abstract
Caffeine, a component of tea, coffee and cola, induces wakefulness. It binds to adenosine A1 and A2A receptors as an antagonist, but the receptor subtype mediating caffeine-induced wakefulness remains unclear. Here we report that caffeine at 5, 10 and 15 mg kg−1 increased wakefulness in both wild-type mice and A1 receptor knockout mice, but not in A2A receptor knockout mice. Thus, caffeine-induced wakefulness depends on adenosine A2A receptors.
- Publication
Nature Neuroscience, 2005, Vol 8, Issue 7, p858
- ISSN
1097-6256
- Publication type
Academic Journal
- DOI
10.1038/nn1491