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- Title
The site of action potential initiation in cerebellar Purkinje neurons.
- Authors
Clark, Beverley A; Monsivais, Pablo; Branco, Tiago; London, Michael; Häusser, Michael
- Abstract
Knowledge of the site of action potential initiation is essential for understanding how synaptic input is converted into neuronal output. Previous studies have shown that the lowest-threshold site for initiation of action potentials is in the axon. Here we use recordings from visualized rat cerebellar Purkinje cell axons to localize the site of initiation to a well-defined anatomical structure: the first node of Ranvier, which normally forms at the first axonal branch point.
- Publication
Nature neuroscience, 2005, Vol 8, Issue 2, p137
- ISSN
1097-6256
- Publication type
Journal Article
- DOI
10.1038/nn1390