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- Title
Pathological gambling is linked to reduced activation of the mesolimbic reward system.
- Authors
Reuter, Jan; Raedler, Thomas; Rose, Michael; Hand, Iver; Gläscher, Jan; Büchel, Christian
- Abstract
By analogy to drug dependence, it has been speculated that the underlying pathology in pathological gambling is a reduction in the sensitivity of the reward system. Studying pathological gamblers and controls during a guessing game using functional magnetic resonance imaging, we observed a reduction of ventral striatal and ventromedial prefrontal activation in the pathological gamblers that was negatively correlated with gambling severity, linking hypoactivation of these areas to disease severity.
- Publication
Nature neuroscience, 2005, Vol 8, Issue 2, p147
- ISSN
1097-6256
- Publication type
Journal Article
- DOI
10.1038/nn1378