We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Focal adhesion kinase in netrin-1 signaling.
- Authors
Xiu-rong Ren; Guo-li Ming; Yi Xie; Yan Hong; Dong-mei Sun; Zhong-qiu Zhao; Zhu Feng; Qiang Wang; Sangwoo Shim; Zhou-feng Chen; Hong-jun Song; Lin Mei; Wen-cheng Xiong
- Abstract
Netrins are a family of secreted molecules that are important for axonal outgrowth and guidance in the developing nervous system. However, the signaling mechanisms that lie immediately downstream of netrin receptors remain poorly understood. Here we report that the netrin receptor DCC (deleted in colorectal cancer) interacts with the focal adhesion kinase (FAK), a kinase implicated in regulating cell adhesion and migration. FAK was expressed in developing brains and was localized with DCC in cultured neurons. Netrin-1 induced FAK and DCC tyrosine phosphorylation. Disruption of FAK signaling abolished netrin-1-induced neurite outgrowth and attractive growth cone turning. Taken together, these results indicate a new signaling mechanism for DCC, in which FAK is activated upon netrin-1 stimulation and mediates netrin-1 function; they also identify a critical role for FAK in axon navigation.
- Publication
Nature Neuroscience, 2004, Vol 7, Issue 11, p1204
- ISSN
1097-6256
- Publication type
Academic Journal
- DOI
10.1038/nn1330