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- Title
Mpdz is a quantitative trait gene for drug withdrawal seizures.
- Authors
Shirley, Renee L; Walter, Nicole A R; Reilly, Matthew T; Fehr, Christoph; Buck, Kari J
- Abstract
Physiological dependence and associated withdrawal episodes can constitute a powerful motivational force that perpetuates drug use and abuse. Using robust behavioral models of drug physiological dependence in mice, positional cloning, and sequence and expression analyses, we identified an addiction-relevant quantitative trait gene, Mpdz. Our findings provide a framework to define the protein interactions and neural circuit by which this gene's product (multiple PDZ domain protein) affects drug dependence, withdrawal and relapse.
- Publication
Nature neuroscience, 2004, Vol 7, Issue 7, p699
- ISSN
1097-6256
- Publication type
Journal Article
- DOI
10.1038/nn1271