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- Title
Circadian regulation of GABA<sub>A</sub> receptor function by CKIe-CKId in the rat suprachiasmatic nuclei.
- Authors
Ke Ning; Lei Li; Mingxiao Liao; Baosong Liu; Mielke, John G.; Yonghong Chen; Ying duan; El-Hayek, Youseff F.; Qi Wan
- Abstract
The type A GABA receptors are thought to mediate synchronization of clock cell activity within the suprachiasmatic nuclei (SCN). Here we report that casein kinases I ε and δ (CKIε and CKIδ), the crucial clock regulators, (form a complex with GABAA (receptors and inhibit the) receptors' function within the SCN according to a circadian rhythm. These results indicate that circadian variation of the (kinase-receptor association may mediate regulation of GABAA receptor function by CKIε- CKIδ in the SCN.
- Publication
Nature Neuroscience, 2004, Vol 7, Issue 5, p489
- ISSN
1097-6256
- Publication type
Academic Journal
- DOI
10.1038/nn1236