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- Title
Layering defect in p35 deficiency is linked to improper neuronal-glial interaction in radial migration.
- Authors
Gupta, Amitabh; Sanada, Kamon; Miyamoto, David T; Rovelstad, Susan; Nadarajah, Bagirathy; Pearlman, Alan L; Brunstrom, Jan; Tsai, Li-Huei
- Abstract
Several genes essential for neocortical layering have been identified in recent years, but their precise roles in this process remain to be elucidated. Mice deficient in p35--an activator of cyclin-dependent kinase 5 (Cdk5)--are characterized by a neocortex that has inverted layering. To decipher the physiological mechanisms that underlie this defect, we compared time-lapse recordings between p35(-/-) and wild-type cortical slices. In the p35(-/-) neocortex, the classic modes of radial migration--somal translocation and locomotion--were largely replaced by a distinct mode of migration: branched migration. Branched migration is cell-autonomous, associated with impaired neuronal-glial interaction and rare in neurons of scrambler mice, which are deficient in Dab1. Hence, our findings suggest that inside-out layering requires distinct functions of Reelin and p35/Cdk5 signaling, with the latter being important for proper glia-guided migration.
- Publication
Nature neuroscience, 2003, Vol 6, Issue 12, p1284
- ISSN
1097-6256
- Publication type
Journal Article
- DOI
10.1038/nn1151