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- Title
Regulation of acetylcholine receptor clustering by the tumor suppressor APC.
- Authors
Junmei Wang; Zheng Jing; Lili Zhang; Guangdou Zhou; Braun, Joe; Yun Yao; Zuo-Zhong Wang
- Abstract
At the developing neuromuscular junction, motor neuron-derived agrin triggers the differentiation of postsynaptic membrane into a highly specialized structure, where the nicotinic acetylcholine receptors (AChRs) are aggregated into high-density clusters. Agrin acts by activating the muscle-specific kinase MuSK and inducing coaggregation of the 43-kDa protein rapsyn with AChRs on muscle cell membrane. The signaling mechanism downstream of MuSK is poorly defined. We report here that the mouse tumor suppressor protein adenomatous polyposis coli (APC) has a role in AChR clustering and that the Wnt/ß-catenin pathway may crosstalk with agrin signaling cascade during synapse formation.
- Publication
Nature Neuroscience, 2003, Vol 6, Issue 10, p1017
- ISSN
1097-6256
- Publication type
Academic Journal
- DOI
10.1038/nn1128