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Title
Plasticity of reward neurocircuitry and the 'dark side' of drug addiction.
Authors
Koob, George F; Le Moal, Michel
Abstract
Drug seeking is associated with activation of reward neural circuitry. Here we argue that drug addiction also involves a 'dark side'--a decrease in the function of normal reward-related neurocircuitry and persistent recruitment of anti-reward systems. Understanding the neuroplasticity of the dark side of this circuitry is the key to understanding vulnerability to addiction.