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- Title
Reinforcing and locomotor stimulant effects of cocaine are absent in mGluR5 null mutant mice.
- Authors
Chiamulera, C; Epping-Jordan, M P; Zocchi, A; Marcon, C; Cottiny, C; Tacconi, S; Corsi, M; Orzi, F; Conquet, F
- Abstract
Both ionotropic and metabotropic glutamate receptors (mGluRs) are involved in the behavioral effects of pyschostimulants; however, the specific contributions of individual mGluR subtypes remain unknown. Here we show that mice lacking the mGluR5 gene do not self-administer cocaine, and show no increased locomotor activity following cocaine treatment, despite showing cocaine-induced increases in nucleus accumbens (NAcc) dopamine (DA) levels similar to wild-type (WT) mice. These results demonstrate a significant contribution of mGlu5 receptors to the behavioral effects of cocaine, and suggest that they may be involved in cocaine addiction.
- Publication
Nature neuroscience, 2001, Vol 4, Issue 9, p873
- ISSN
1097-6256
- Publication type
Journal Article
- DOI
10.1038/nn0901-873