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- Title
Opposing actions of protein kinase A and C mediate Hebbian synaptic plasticity.
- Authors
Li, M X; Jia, M; Jiang, H; Dunlap, V; Nelson, P G
- Abstract
A compartmental nerve-muscle tissue culture system expresses Hebbian activity-dependent synapse modulation. Protein kinase C (PKC) mediates a heterosynaptic loss of efficacy, and we now show that protein kinase A (PKA) is involved in homosynaptic stabilization. Both work through postsynaptic changes in the acetylcholine receptor (AChR) as measured electrophysiologically and by imaging techniques.
- Publication
Nature neuroscience, 2001, Vol 4, Issue 9, p871
- ISSN
1097-6256
- Publication type
Journal Article
- DOI
10.1038/nn0901-871