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- Title
Parvalbumin interneurons mediate neuronal circuitry-neurogenesis coupling in the adult hippocampus.
- Authors
Song, Juan; Sun, Jiaqi; Moss, Jonathan; Wen, Zhexing; Sun, Gerald J; Hsu, Derek; Zhong, Chun; Davoudi, Heydar; Christian, Kimberly M; Toni, Nicolas; Ming, Guo-Li; Song, Hongjun
- Abstract
Using immunohistology, electron microscopy, electrophysiology and optogenetics, we found that proliferating adult mouse hippocampal neural precursors received immature GABAergic synaptic inputs from parvalbumin-expressing interneurons. Recently shown to suppress adult quiescent neural stem cell activation, parvalbumin interneuron activation promoted newborn neuronal progeny survival and development. Our results suggest a niche mechanism involving parvalbumin interneurons that couples local circuit activity to the diametric regulation of two critical early phases of adult hippocampal neurogenesis.
- Publication
Nature neuroscience, 2013, Vol 16, Issue 12, p1728
- ISSN
1546-1726
- Publication type
Journal Article
- DOI
10.1038/nn.3572