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- Title
Corticostriatal functional connectivity predicts transition to chronic back pain.
- Authors
Baliki, Marwan N; Petre, Bogdan; Torbey, Souraya; Herrmann, Kristina M; Huang, Lejian; Schnitzer, Thomas J; Fields, Howard L; Apkarian, A Vania
- Abstract
The mechanism of brain reorganization in pain chronification is unknown. In a longitudinal brain imaging study, subacute back pain (SBP) patients were followed over the course of 1 year. When pain persisted (SBPp, in contrast to recovering SBP and healthy controls), brain gray matter density decreased. Initially greater functional connectivity of nucleus accumbens with prefrontal cortex predicted pain persistence, implying that corticostriatal circuitry is causally involved in the transition from acute to chronic pain.
- Publication
Nature neuroscience, 2012, Vol 15, Issue 8, p1117
- ISSN
1546-1726
- Publication type
Journal Article
- DOI
10.1038/nn.3153