We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Tanycytes of the hypothalamic median eminence form a diet-responsive neurogenic niche.
- Authors
Lee, Daniel A; Bedont, Joseph L; Pak, Thomas; Wang, Hong; Song, Juan; Miranda-Angulo, Ana; Takiar, Vani; Charubhumi, Vanessa; Balordi, Francesca; Takebayashi, Hirohide; Aja, Susan; Ford, Eric; Fishell, Gordon; Blackshaw, Seth
- Abstract
Adult hypothalamic neurogenesis has recently been reported, but the cell of origin and the function of these newborn neurons are unknown. Using genetic fate mapping, we found that median eminence tanycytes generate newborn neurons. Blocking this neurogenesis altered the weight and metabolic activity of adult mice. These findings reveal a previously unreported neurogenic niche in the mammalian hypothalamus with important implications for metabolism.
- Publication
Nature neuroscience, 2012, Vol 15, Issue 5, p700
- ISSN
1546-1726
- Publication type
Journal Article
- DOI
10.1038/nn.3079