We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Rhes, a striatal-enriched small G protein, mediates mTOR signaling and L-DOPA-induced dyskinesia.
- Authors
Subramaniam, Srinivasa; Napolitano, Francesco; Mealer, Robert G; Kim, Seyun; Errico, Francesco; Barrow, Roxanne; Shahani, Neelam; Tyagi, Richa; Snyder, Solomon H; Usiello, Alessandro
- Abstract
L-DOPA-induced dyskinesia, the rate-limiting side effect in the therapy of Parkinson's disease, is mediated by activation of mammalian target of rapamycin (mTOR) signaling in the striatum. We found that Ras homolog enriched in striatum (Rhes), a striatal-specific protein, binds to and activates mTOR. Moreover, Rhes?/? mice showed reduced striatal mTOR signaling and diminished dyskinesia, but maintained motor improvement on L-DOPA treatment, suggesting a therapeutic benefit for Rhes-binding drugs.
- Publication
Nature Neuroscience, 2012, Vol 15, Issue 2, p191
- ISSN
1097-6256
- Publication type
Academic Journal
- DOI
10.1038/nn.2994