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- Title
Perivascular instruction of cell genesis and fate in the adult brain.
- Authors
Goldman, Steven A; Chen, Zhuoxun
- Abstract
The perivascular niche for neurogenesis was first reported as the co-association of newly generated neurons and their progenitors with both dividing and mitotically quiescent endothelial cells in restricted regions of the brain in adult birds and mammals alike. This review attempts to summarize our present understanding of the interaction of blood vessels with neural stem and progenitor cells, addressing both glial and neuronal progenitor cell interactions in the perivascular niche. We review the molecular interactions that are most critical to the endothelial control of stem and progenitor cell mobilization and differentiation. The focus throughout will be on defining those perivascular ligand-receptor interactions shared among these systems, as well as those that clearly differ as a function of cell type and setting, by which specificity may be achieved in the development of targeted therapeutics.
- Publication
Nature neuroscience, 2011, Vol 14, Issue 11, p1382
- ISSN
1546-1726
- Publication type
Journal Article
- DOI
10.1038/nn.2963