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- Title
Presenilin 1 regulates homeostatic synaptic scaling through Akt signaling.
- Authors
Pratt, Kara G; Zimmerman, Eric C; Cook, David G; Sullivan, Jane M
- Abstract
Neurons adapt to long-lasting changes in network activity, both in vivo and in vitro, by adjusting their synaptic strengths to stabilize firing rates. We found that homeostatic scaling of excitatory synapses was impaired in hippocampal neurons derived from mice lacking presenilin 1 (Psen1(-/-) mice) or expressing a familial Alzheimer's disease-linked Psen1 mutation (Psen1(M146V)). These findings suggest that deficits in synaptic homeostasis may contribute to brain dysfunction in Alzheimer's disease.
- Publication
Nature neuroscience, 2011, Vol 14, Issue 9, p1112
- ISSN
1546-1726
- Publication type
Journal Article
- DOI
10.1038/nn.2893