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- Title
Nutritional omega-3 deficiency abolishes endocannabinoid-mediated neuronal functions.
- Authors
Lafourcade, Mathieu; Larrieu, Thomas; Mato, Susana; Duffaud, Anais; Sepers, Marja; Matias, Isabelle; De Smedt-Peyrusse, Veronique; Labrousse, Virginie F; Bretillon, Lionel; Matute, Carlos; Rodríguez-Puertas, Rafael; Layé, Sophie; Manzoni, Olivier J
- Abstract
The corollaries of the obesity epidemic that plagues developed societies are malnutrition and resulting biochemical imbalances. Low levels of essential n-3 polyunsaturated fatty acids (n-3 PUFAs) have been linked to neuropsychiatric diseases, but the underlying synaptic alterations are mostly unknown. We found that lifelong n-3 PUFAs dietary insufficiency specifically ablates long-term synaptic depression mediated by endocannabinoids in the prelimbic prefrontal cortex and accumbens. In n-3-deficient mice, presynaptic cannabinoid CB(1) receptors (CB(1)Rs) normally responding to endocannabinoids were uncoupled from their effector G(i/o) proteins. Finally, the dietary-induced reduction of CB(1)R functions in mood-controlling structures was associated with impaired emotional behavior. These findings identify a plausible synaptic substrate for the behavioral alterations caused by the n-3 PUFAs deficiency that is often observed in western diets.
- Publication
Nature neuroscience, 2011, Vol 14, Issue 3, p345
- ISSN
1546-1726
- Publication type
Journal Article
- DOI
10.1038/nn.2736