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- Title
Characterization of the proteome, diseases and evolution of the human postsynaptic density.
- Authors
Bayés, Alex; van de Lagemaat, Louie N; Collins, Mark O; Croning, Mike D R; Whittle, Ian R; Choudhary, Jyoti S; Grant, Seth G N
- Abstract
We isolated the postsynaptic density from human neocortex (hPSD) and identified 1,461 proteins. hPSD mutations cause 133 neurological and psychiatric diseases and were enriched in cognitive, affective and motor phenotypes underpinned by sets of genes. Strong protein sequence conservation in mammalian lineages, particularly in hub proteins, indicates conserved function and organization in primate and rodent models. The hPSD is an important structure for nervous system disease and behavior.
- Publication
Nature neuroscience, 2011, Vol 14, Issue 1, p19
- ISSN
1546-1726
- Publication type
Journal Article
- DOI
10.1038/nn.2719