We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Fezf2 directs the differentiation of corticofugal neurons from striatal progenitors in vivo.
- Authors
Rouaux, Caroline; Arlotta, Paola
- Abstract
In the developing cerebral cortex, cell-extrinsic and cell-intrinsic signals govern the establishment of neuron subtype-specific identity. Here we show that, within the niche of the striatum, the expression of a single transcription factor, Fezf2, is sufficient to generate corticofugal neurons from progenitors fated to become medium spiny neurons. This demonstrates that a specific population of cortical projection neurons can be directed to differentiate outside of the cortex by cell-autonomous signaling.
- Publication
Nature neuroscience, 2010, Vol 13, Issue 11, p1345
- ISSN
1546-1726
- Publication type
Journal Article
- DOI
10.1038/nn.2658