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- Title
miR-124 regulates adult neurogenesis in the subventricular zone stem cell niche.
- Authors
Li-Chun Cheng; Pastrana, Erika; Tavazoie, Masoud; Doetsch, Fiona
- Abstract
The subventricular zone (SVZ) is the largest neurogenic niche in the adult mammalian brain. We found that the brain-enriched microRNA miR-124 is an important regulator of the temporal progression of adult neurogenesis in mice. Knockdown of endogenous miR-124 maintained purified SVZ stem cells as dividing precursors, whereas ectopic expression led to precocious and increased neuron formation. Furthermore, blocking miR-124 function during regeneration led to hyperplasias, followed by a delayed burst of neurogenesis. We identified the SRY-box transcription factor Sox9 as being a physiological target of miR-124 at the transition from the transit amplifying cell to the neuroblast stage. Sox9 overexpression abolished neuronal differentiation, whereas Sox9 knockdown led to increased neuron formation. Thus miR-124–mediated repression of Sox9 is important for progression along the SVZ stem cell lineage to neurons.
- Publication
Nature Neuroscience, 2009, Vol 12, Issue 4, p399
- ISSN
1097-6256
- Publication type
Academic Journal
- DOI
10.1038/nn.2294