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- Title
Genotyping over 100,000 SNPs on a pair of oligonucleotide arrays.
- Authors
Matsuzaki, Hajime; Dong, Shoulian; Loi, Halina; Di, Xiaojun; Liu, Guoying; Hubbell, Earl; Law, Jane; Berntsen, Tam; Chadha, Monica; Hui, Henry; Yang, Geoffrey; Kennedy, Giulia C; Webster, Teresa A; Cawley, Simon; Walsh, P Sean; Jones, Keith W; Fodor, Stephen P A; Mei, Rui
- Abstract
We present a genotyping method for simultaneously scoring 116,204 SNPs using oligonucleotide arrays. At call rates >99%, reproducibility is >99.97% and accuracy, as measured by inheritance in trios and concordance with the HapMap Project, is >99.7%. Average intermarker distance is 23.6 kb, and 92% of the genome is within 100 kb of a SNP marker. Average heterozygosity is 0.30, with 105,511 SNPs having minor allele frequencies >5%.
- Publication
Nature methods, 2004, Vol 1, Issue 2, p109
- ISSN
1548-7091
- Publication type
Journal Article
- DOI
10.1038/nmeth718