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- Title
Protein engineers turned evolutionists.
- Authors
Peisajovich, Sergio G; Tawfik, Dan S
- Abstract
When generating novel tailor-made proteins, protein engineers routinely apply the principles of 'Darwinian' evolution. However, laboratory evolution of proteins also has the potential to test evolutionary theories and reproduce evolutionary scenarios, thus reconstructing putative protein intermediates and providing a glimpse of 'protein fossils'. This commentary describes research at the interface of applied and fundamental molecular evolution, and provides a personal view of how synergy between fundamental and applied experiments indicates novel and more efficient ways of generating new proteins in the laboratory.
- Publication
Nature methods, 2007, Vol 4, Issue 12, p991
- ISSN
1548-7105
- Publication type
Journal Article
- DOI
10.1038/nmeth1207-991