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- Title
Microarray-based genomic selection for high-throughput resequencing.
- Authors
Okou, David T; Steinberg, Karyn Meltz; Middle, Christina; Cutler, David J; Albert, Thomas J; Zwick, Michael E
- Abstract
We developed a general method, microarray-based genomic selection (MGS), capable of selecting and enriching targeted sequences from complex eukaryotic genomes without the repeat blocking steps necessary for bacterial artificial chromosome (BAC)-based genomic selection. We demonstrate that large human genomic regions, on the order of hundreds of kilobases, can be enriched and resequenced with resequencing arrays. MGS, when combined with a next-generation resequencing technology, can enable large-scale resequencing in single-investigator laboratories.
- Publication
Nature methods, 2007, Vol 4, Issue 11, p907
- ISSN
1548-7091
- Publication type
Journal Article
- DOI
10.1038/nmeth1109