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- Title
Decoding protein modifications using top-down mass spectrometry.
- Authors
Siuti, Nertila; Kelleher, Neil L
- Abstract
Top-down mass spectrometry is an emerging technology which strives to preserve the post-translationally modified forms of proteins present in vivo by measuring them intact, rather than measuring peptides produced from them by proteolysis. The top-down technology is beginning to capture the interest of biologists and mass spectrometrists alike, with a main goal of deciphering interaction networks operative in cellular pathways. Here we outline recent approaches and applications of top-down mass spectrometry as well as an outlook for its future.
- Publication
Nature methods, 2007, Vol 4, Issue 10, p817
- ISSN
1548-7091
- Publication type
Journal Article
- DOI
10.1038/nmeth1097