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- Title
A model system for analyzing somatic mutations in Drosophila melanogaster.
- Authors
Garcia, Ana Maria; Derventzi, Anastasia; Busuttil, Rita; Calder, R Brent; Perez, Ernesto, Jr; Chadwell, Linda; Dollé, Martijn E T; Lundell, Martha; Vijg, Jan
- Abstract
Presently there are no good assays for comparing somatic mutation frequencies and spectra between different vertebrate and invertebrate organisms. Here we describe a new lacZ mutation reporter system in D. melanogaster, which complements existing systems in the mouse. The results obtained with the new model indicate two-to threefold higher frequencies of spontaneous mutations than in the mouse, with most of the mutations characterized as large genome rearrangements.
- Publication
Nature methods, 2007, Vol 4, Issue 5, p401
- ISSN
1548-7091
- Publication type
Journal Article
- DOI
10.1038/nmeth1027