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- Title
Transposon-tagged mutagenesis in the rat.
- Authors
Kitada, Kazuhiro; Ishishita, Satoshi; Tosaka, Keiko; Takahashi, Ri-ichi; Ueda, Masatsugu; Keng, Vincent W; Horie, Kyoji; Takeda, Junji
- Abstract
Although the laboratory rat (Rattus norvegicus) is an indispensable experimental animal for biomedical research and drug development, the lack of embryonic stem cell lines hampers gene-knockout studies. Here we report the successful generation of insertional mutant rats using the Sleeping Beauty (SB) transposon system. This would benefit a variety of biomedical research fields for which the rat model is better suited than the mouse model.
- Publication
Nature methods, 2007, Vol 4, Issue 2, p131
- ISSN
1548-7091
- Publication type
Journal Article
- DOI
10.1038/nmeth1002