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- Title
Sequencing: High-resolution chromatin immunoprecipitation.
- Authors
Nawy, Tal
- Abstract
The article presents information on a research conducted on chromatin immunoprecipitation (ChIP). ChIP is used to find where proteins physically associate with genomic DNA. Protein-DNA interactions are stabilized by crosslinking, and binding of chromatin to a specific protein selectively enriched by immunoprecipitation. Researchers at Pennsylvania State University added exonuclease to immunoprecipitated DNA while it was bound to resin, protecting it at protein-bound sites.
- Publication
Nature Methods, 2012, Vol 9, Issue 2, p130
- ISSN
1548-7091
- Publication type
Academic Journal
- DOI
10.1038/nmeth.1887