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- Title
Measurement of mechanical tractions exerted by cells in three-dimensional matrices.
- Authors
Legant, Wesley R; Miller, Jordan S; Blakely, Brandon L; Cohen, Daniel M; Genin, Guy M; Chen, Christopher S
- Abstract
Quantitative measurements of cell-generated forces have heretofore required that cells be cultured on two-dimensional substrates. We describe a technique to quantitatively measure three-dimensional traction forces exerted by cells fully encapsulated in well-defined elastic hydrogel matrices. Using this approach we measured traction forces for several cell types in various contexts and revealed patterns of force generation attributable to morphologically distinct regions of cells as they extend into the surrounding matrix.
- Publication
Nature methods, 2010, Vol 7, Issue 12, p969
- ISSN
1548-7105
- Publication type
Journal Article
- DOI
10.1038/nmeth.1531