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Title
Direct determination of molecular haplotypes by chromosome microdissection.
Authors
Li Ma; Yan Xiao; Hui Huang; Qingwei Wang; Weinian Rao; Yue Feng; Kui Zhang; Qing Song
Abstract
Direct observation of haplotypes is still technically challenging. Here we report a method for the determination of haplotypes through chromosome microdissection. We determined human long-range chromosomal haplotypes with more than 98.85% accuracy at 24,245 genome-wide heterozygous single-nucleotide polymorphism (SNP) loci.