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- Title
A reprogrammable mouse strain from gene-targeted embryonic stem cells.
- Authors
Stadtfeld, Matthias; Maherali, Nimet; Borkent, Marti; Hochedlinger, Konrad
- Abstract
The derivation of induced pluripotent stem cells (iPSCs) usually involves the viral introduction of reprogramming factors into somatic cells. Here we used gene targeting to generate a mouse strain with a single copy of an inducible, polycistronic reprogramming cassette, allowing for the induction of pluripotency in various somatic cell types. As these 'reprogrammable mice' can be easily bred, they are a useful tool to study the mechanisms underlying cellular reprogramming.
- Publication
Nature methods, 2010, Vol 7, Issue 1, p53
- ISSN
1548-7105
- Publication type
Journal Article
- DOI
10.1038/nmeth.1409