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- Title
Sense from sequence reads: methods for alignment and assembly.
- Authors
Flicek, Paul; Birney, Ewan
- Abstract
The most important first step in understanding next-generation sequencing data is the initial alignment or assembly that determines whether an experiment has succeeded and provides a first glimpse into the results. In parallel with the growth of new sequencing technologies, several algorithms that align or assemble the large data output of today's sequencing machines have been developed. We discuss the current algorithmic approaches and future directions of these fundamental tools and provide specific examples for some commonly used tools.
- Publication
Nature methods, 2009, Vol 6, Issue 11 Suppl, pS6
- ISSN
1548-7105
- Publication type
Journal Article
- DOI
10.1038/nmeth.1376