We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Intravital imaging of metastatic behavior through a mammary imaging window.
- Authors
Kedrin, Dmitriy; Gligorijevic, Bojana; Wyckoff, Jeffrey; Verkhusha, Vladislav V; Condeelis, John; Segall, Jeffrey E; van Rheenen, Jacco
- Abstract
We report a technique to evaluate the same tumor microenvironment over multiple intravital imaging sessions in living mice. We optically marked individual tumor cells expressing photoswitchable proteins in an orthotopic mammary carcinoma and followed them for extended periods through a mammary imaging window. We found that two distinct microenvironments in the same orthotopic mammary tumor affected differently the invasion and intravasation of tumor cells.
- Publication
Nature methods, 2008, Vol 5, Issue 12, p1019
- ISSN
1548-7105
- Publication type
Journal Article
- DOI
10.1038/nmeth.1269