We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Native mass spectrometry: a bridge between interactomics and structural biology.
- Authors
Heck, Albert J R
- Abstract
Native mass spectrometry is an emerging technology that allows the topological investigation of intact protein complexes with high sensitivity and a theoretically unrestricted mass range. This unique tool provides complementary information to established technologies in structural biology, and also provides a link to high-throughput interactomics studies, which do not generate information on exact protein complex-composition, structure or dynamics. Here I review the current state of native mass spectrometry technology and discuss several important biological applications. I also describe current experimental challenges in native mass spectrometry, encouraging readers to contribute to solutions.
- Publication
Nature methods, 2008, Vol 5, Issue 11, p927
- ISSN
1548-7105
- Publication type
Journal Article
- DOI
10.1038/nmeth.1265