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- Title
Linking SNPs to CAG repeat length in Huntington's disease patients.
- Authors
Wanzhao Liu; Kennington, Lori A.; Rosas, H. Diana; Hersch, Steven; Jang-Ho Cha; Zamore, Phillip D.; Aronin, Neil
- Abstract
Allele-specific silencing using small interfering RNAs targeting heterozygous single-nucleotide polymorphisms (SNPs) is a promising therapy for human trinucleotide repeat diseases such as Huntington's disease. Linking SNP identities to the two HTT alleles, normal and disease-causing, is a prerequisite for allele-specific RNA interference. Here we describe a method, SNP linkage by circularization (SLiC), to identify linkage between CAG repeat length and nucleotide identity of heterozygous SNPs using Huntington's disease patient peripheral blood samples.
- Publication
Nature Methods, 2008, Vol 5, Issue 11, p951
- ISSN
1548-7091
- Publication type
Academic Journal
- DOI
10.1038/nmeth.1261