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- Title
Escape of malaria parasites from host immunity requires CD4<sup>+</sup>CD25<sup>+</sup> regulatory T cells.
- Authors
Hisaeda, Hajime; Maekawa, Yoichi; Daiji Iwakawa, Yoichi; Hiroko Okada; Kunisuke Himeno, Yoichi; Kenji Kishihara; Shin-ichi Tsukumo; Koji Yasutomo
- Abstract
Infection with malaria parasites frequently induces total immune suppression, which makes it difficult for the host to maintain long-lasting immunity. Here we show that depletion of CD4+CD25+ regulatory T cells (Treg) protects mice from death when infected with a lethal strain of Plasmodium yoelii, and that this protection is associated with an increased T-cell responsiveness against parasite-derived antigens. These results suggest that activation of Treg cells contributes to immune suppression during malaria infection, and helps malaria parasites to escape from host immune responses.
- Publication
Nature Medicine, 2004, Vol 10, Issue 1, p29
- ISSN
1078-8956
- Publication type
Academic Journal
- DOI
10.1038/nm975