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- Title
Hsp70 promotes antigen-presenting cell function and converts T-cell tolerance to autoimmunity in vivo.
- Authors
Millar, Douglas G; Garza, Kristine M; Odermatt, Bernhard; Elford, Alisha R; Ono, Nobuyuki; Li, Zihai; Ohashi, Pamela S
- Abstract
Pathogens or pathogen-associated molecular patterns can signal to cells of the innate immune system and trigger effective adaptive immunity. However, relatively little is known about how the innate immune system detects tissue injury or necrosis. Evidence suggests that the release of heat-shock proteins (HSPs) may provide adjuvant-like signals, but the ability of HSPs to promote activation or tolerance in vivo has not been addressed. In this study we show that Hsp70 promotes dendritic cell (DC) function and, together with antigen, triggers autoimmune disease in vivo.
- Publication
Nature medicine, 2003, Vol 9, Issue 12, p1469
- ISSN
1078-8956
- Publication type
Journal Article
- DOI
10.1038/nm962