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- Title
Post-transplant Kaposi sarcoma originates from the seeding of donor-derived progenitors.
- Authors
Barozzi, Patrizia; Luppi, Mario; Facchetti, Fabio; Mecucci, Cristina; Alù, Milena; Sarid, Ronit; Rasini, Valeria; Ravazzini, Luisa; Rossi, Elisa; Festa, Silvana; Crescenzi, Barbara; Wolf, Dana G; Schulz, Thomas F; Torelli, Giuseppe
- Abstract
Kaposi sarcoma (KS) is a vascular tumor that can develop in recipients of solid tissue transplants as a result of either primary infection or reactivation of a gammaherpesvirus, the KS- associated herpesvirus, also known as human herpesvirus-8 (HHV-8). We studied whether HHV-8 and the elusive KS progenitor cells could be transmitted from the donor through the grafts. We used a variety of molecular, cytogenetic, immunohistochemical and immunofluorescence methods to show that the HHV-8-infected neoplastic cells in post-transplant KS from five of eight renal transplant patients harbored either genetic or antigenic markers of their matched donors. These data suggest the use of donor-derived HHV-8-specific T cells for the control of post-transplant KS.
- Publication
Nature medicine, 2003, Vol 9, Issue 5, p554
- ISSN
1078-8956
- Publication type
Journal Article
- DOI
10.1038/nm862