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- Title
Generation of antibodies specific for beta-amyloid by vaccination of patients with Alzheimer disease.
- Authors
Hock, Christoph; Konietzko, Uwe; Papassotiropoulos, Andreas; Wollmer, Axel; Streffer, Johannes; von Rotz, Ruth C; Davey, Gabriela; Moritz, Eva; Nitsch, Roger M
- Abstract
To characterize antibodies produced in humans in response to Abeta42 vaccination, we carried out immunohistochemical examinations of the brains of both transgenic mice and human patients with beta-amyloid pathology. We collected sera from patients with Alzheimer disease who received a primary injection of pre-aggregated Abeta42 followed by one booster injection in a placebo-controlled study. Antibodies in immune sera recognized beta-amyloid plaques, diffuse Abeta deposits and vascular beta-amyloid in brain blood vessels. The antibodies did not cross-react with native full-length beta-amyloid precursor protein or its physiological derivatives, including soluble Abeta42. These findings indicate that vaccination of AD patients with Abeta42 induces antibodies that have a high degree of selectivity for the pathogenic target structures. Whether vaccination to produce antibodies against beta-amyloid will halt the cognitive decline in AD will depend upon clinical assessments over time.
- Publication
Nature medicine, 2002, Vol 8, Issue 11, p1270
- ISSN
1078-8956
- Publication type
Journal Article
- DOI
10.1038/nm783