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- Title
Molecular imaging of lymphoid organs and immune activation by positron emission tomography with a new [<sup>18</sup>F]-labeled 2′-deoxycytidine analog.
- Authors
Radu, Caius G.; Shu, Chengyi J.; Nair-Gill, Evan; Shelly, Stephanie M.; Barrio, Jorge R.; Satyamurthy, Nagichettiar; Phelps, Michael E.; Witte, Owen N.
- Abstract
Monitoring immune function with molecular imaging could have a considerable impact on the diagnosis and treatment evaluation of immunological disorders and therapeutic immune responses. Positron emission tomography (PET) is a molecular imaging modality with applications in cancer and other diseases. PET studies of immune function have been limited by a lack of specialized probes. We identified [18F]FAC (1-(2′-deoxy-2′-[18F]fluoroarabinofuranosyl) cytosine) by differential screening as a new PET probe for the deoxyribonucleotide salvage pathway. [18F]FAC enabled visualization of lymphoid organs and was sensitive to localized immune activation in a mouse model of antitumor immunity. [18F]FAC microPET also detected early changes in lymphoid mass in systemic autoimmunity and allowed evaluation of immunosuppressive therapy. These data support the use of [18F]FAC PET for immune monitoring and suggest a wide range of clinical applications in immune disorders and in certain types of cancer.
- Publication
Nature Medicine, 2008, Vol 14, Issue 7, p783
- ISSN
1078-8956
- Publication type
Academic Journal
- DOI
10.1038/nm1724