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- Title
Antielastin autoimmunity in tobacco smoking–induced emphysema.
- Authors
Seung-Hyo Lee; Goswami, Sangeeta; Grudo, Ariel; Li-zhen Song; Bandi, Venkata; Goodnight-White, Sheila; Green, Linda; Hacken-Bitar, Joan; Huh, Joseph; Bakaeen, Faisal; Coxson, Harvey O.; Cogswell, Sebastian; Storness-Bliss, Claudine; Corry, David B.; Kheradmand, Farrah
- Abstract
Chronic obstructive pulmonary disease and emphysema are common destructive inflammatory diseases that are leading causes of death worldwide. Here we show that emphysema is an autoimmune disease characterized by the presence of antielastin antibody and T-helper type 1 (TH1) responses, which correlate with emphysema severity. These findings link emphysema to adaptive immunity against a specific lung antigen and suggest the potential for autoimmune pathology of other elastin-rich tissues such as the arteries and skin of smokers.
- Publication
Nature Medicine, 2007, Vol 13, Issue 5, p567
- ISSN
1078-8956
- Publication type
Academic Journal
- DOI
10.1038/nm1583