We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Tropism of avian influenza A (H5N1) in the upper and lower respiratory tract.
- Authors
Nicholls, J M; Chan, M C W; Chan, W Y; Wong, H K; Cheung, C Y; Kwong, D L W; Wong, M P; Chui, W H; Poon, L L M; Tsao, S W; Guan, Y; Peiris, J S M
- Abstract
Poor human-to-human transmission of influenza A H5N1 virus has been attributed to the paucity of putative sialic acid alpha2-3 virus receptors in the epithelium of the human upper respiratory tract, and thus to the presumed inability of the virus to replicate efficiently at this site. We now demonstrate that ex vivo cultures of human nasopharyngeal, adenoid and tonsillar tissues can be infected with H5N1 viruses in spite of an apparent lack of these receptors.
- Publication
Nature medicine, 2007, Vol 13, Issue 2, p147
- ISSN
1078-8956
- Publication type
Journal Article
- DOI
10.1038/nm1529